Hexafluoroisopropanol, commonly abbreviated HFIP, is the organic compound with the formula (CF3)2CHOH. This fluorinated alcohol finds use as solvent and synthetic intermediate. It appears as a colorless, volatile liquid that is characterized by a strong, pungent odor. As a solvent hexafluoro-2-propanol is polar and exhibits strong hydrogen bonding properties enabling it to dissolve substances that serve as hydrogen-bond acceptors, such as amides and ethers. Hexafluoro-2-propanol is transparent to UV light with high density, low viscosity and low refractive index.
Video Hexafluoro-2-propanol
Production and uses
Hexafluoro-2-propanol is prepared from hexafluoropropylene via hexafluoroacetone, which is then hydrogenated.
- (CF3)2CO + H2 -> (CF3)2CHOH
Hexafluoro-2-propanol is a speciality solvent for some polar polymers and organic synthesis. It is especially effective for solubilizing a wide range of polymers, including those that are not soluble in the most common organic solvents, such as: polyamides, polyacrylonitriles, polyacetals, polyesters (e.g. polyglycolide), and polyketones. It has also found use in biochemistry to solubilize peptides and to monomerize ?-sheet protein aggregates. Because of its acidity (pKa = 9.3), it can be used as acid in volatile buffers for ion pair HPLC - mass spectrometry of nucleic acids.
Maps Hexafluoro-2-propanol
Medicine
It is both the precursor and the chief metabolite of the inhalation anesthetic sevoflurane.
Safety
Hexafluoro-2-propanol is a volatile, corrosive liquid that can cause severe burns and respiratory problems.
References
Notes
Sources
External links
- Application note on quantification of HFIP in polymers
Source of the article : Wikipedia
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